N-metil-D-aspartinska kiselina

N-Metil-D-aspartinska kiselina
Ball and stick model of N-methyl-D-aspartic acid	Spacefill model of N-methyl-D-aspartic acid
Nazivi
	IUPAC naziv (2R)-2-(Metolamino)butandioinska kiselina
Identifikacija
CAS broj	6384-92-5 ;
3D model (Jmol)	interaktivna slika;
Abrevijacija	NMDA
Bajlštajn	1724431
ChEBI	CHEBI:31882 ;
ChemSpider	21436 ;
KEGG	C12269 ;
MeSH	N-Methylaspartate
PubChem C ID	22880;
RTECS	CI9457000
	SMILES CN[C@H](CC(O)=O)C(O)=O; ; ; ; ; ;
Svojstva
Hemijska formula	C5H9NO4
Molarna masa	147,13 g·mol−1
Agregatno stanje	Beli, neprozirni kritali
Miris	Bez mirisa
log P	1,39
Kiselost (pKa)	2,206
Baznost (pKb)	11,791
Opasnosti
S-oznake	S22, S24/25
	Letalna doza ili koncentracija (LD, LC):
LD50 (LD50)	137 mg kg−1 (intraperitonealno, miš)
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

N-Metil-D-aspartinska kiselina (N-metil-D-aspartat, NMDA) je aminokiselinski derivat koji deluje kao specifični agonist NMDA receptora. NMDA oponaša dejstvo glutamata, neurotransmitera koji je endogeni ligand tog receptora. Za razliju od glutamata, NMDA se jedino vezuje za i reguliše NMDA receptore, i nema efekta na druge tipove glutamatnih receptora (kao što su AMPA i kainatni). NMDA receptori su posebno važni kad postanu prekomerno aktivni tokom povlačenja alkohola, a to uzrokuje simptome poput agitacije, i u nekim slučajevima epileptičke napade.

Reference

^ „N-Methylaspartate - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 24. 6. 2005. Identification and Related Records. Приступљено 9. 1. 2012.
^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

Literatura

Mathias-Costa Blaise; Ramanathan Sowdhamini; Metpally Rau Raghu Prasad; Nithyananda Pradhan (2004). „Evolutionary trace analysis of ionotropic glutamate receptor sequences and modeling the interactions of agonists with different NMDA receptor subunits”. J. Mol. Model. 10 (5-6): 305—16. PMID 15597199. doi:10.1007/s00894-004-0196-7.

[1] „N-Methylaspartate - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 24. 6. 2005. Identification and Related Records. Приступљено 9. 1. 2012.

[2] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[3] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[4] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[1]

[2]

[3]

[4]