Kortikotropin-oslobađajući hormon

Kortikotropin-oslobađajući hormon
Kortikotropin-oslobađajući hormon
	PDB prikaz baziran na 1go9.
Dostupne strukture
	1go9, 1goe
Identifikatori
Simboli	CRH; CRF
Vanjski ID	OMIM: 122560 MGI: 88496 HomoloGene: 599 GeneCards: CRH Gene
Ontologija gena
Molekularna funkcija	• aktivnost neuropeptidnog hormona;
Celularna komponenta	• ekstracelularni region; • rastvorna frakcija;
Biološki proces	• imunski respons; • prenos signal; • sinaptička transmisija; • trudnoća; • porođaj; • učenje i/ili memorija;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	1392
Ensembl	ENSG00000147571
UniProt	P06850
RefSeq (mRNA)	NM_000756
RefSeq (protein)	NP_000747
Lokacija (UCSC)	Chr 8:; 67.25 - 67.25 Mb
PubMed pretraga	[1]

Kortikotropin-oslobađajući hormon (CRH, originalno nazvan kortikotropin-oslobađajući faktor, CRF, takođe poznat kao kortikoliberin), je polipeptidni hormon i neurotransmiter koji učestvuje u odgovoru organizma na stres. On pripada familiji kortikotropin-oslobađajućih faktora.

Njegova glavna funkcija je stimulacija hipofizne sinteze adrenokortikotropnog hormona.

Kortikotropin-oslobađajuči hormon je 41-aminokiselina dug peptid izveden iz 191-aminokiselinskog preprohormona. CRH izlučuje paraventrikularni nukleus (PVN) hipotalamusa u odgovoru na stres. Primetno umanjenje CRH koncentracije je bilo primećeno kod obolelih od Alchajmerove bolesti. Osim što se proizvodi u hipotalamusu, CRH je takođe sintetisan u perifernim tkivima, poput T limfocita, i visoko je izražen u posteljici. U posteljici je CRH služi kao indikator koji određuje dužinu gestacije i vreme porođaja. Brzo povišenje CRH nivoa u cirkulaciji se javlja na početku porođaja.^[1]

Struktura

CRH su otkrili Vale et al. kod ovaca 1981.^[2] Njegova sekvenca je:

SQEPPISLDLTFHLLREVLEMTKADQLAQQAHSNRKLLDIA

Peptidi pacova i čoveka su identični i razlikuju se od ovčije sekvence za samo 7 aminokiselina.^[3]

SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII

Interakcije

Za kortikotropin-oslobađajući hormon je pokazano da interaguje sa kortikotropin-oslobađajućim hormonskim receptorom 1.^[4]^[5]

Vidi još

Reference

^ „Entrez Gene: CRH corticotropin releasing hormone”.
^ Vale W, Spiess J, Rivier C, Rivier J (1981). „Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin”. Science (journal). 213 (4514): 1394—7. PMID 6267699. doi:10.1126/science.6267699.
^ Chrousos GP, Schuermeyer TH, Doppman J, Oldfield EH, Schulte HM, Gold PW, Loriaux DL (1985). „NIH conference. Clinical applications of corticotropin-releasing factor.”. Annals of internal medicine. 102 (3): 344—358. PMID 2982307.
^ Grammatopoulos, D K; Dai Y; et al. (1999). „A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes”. Mol. Endocrinol. UNITED STATES. 13 (12): 2189—202. ISSN 0888-8809. PMID 10598591. doi:10.1210/me.13.12.2189.
^ Gottowik, J; Goetschy V; et al. (1997). „Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin”. Neuropharmacology. ENGLAND. 36 (10): 1439—46. ISSN 0028-3908. PMID 9423932. doi:10.1016/S0028-3908(97)00098-1.

Literatura

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Perone MJ; Murray CA; Brown OA; et al. (1998). „Procorticotrophin-releasing hormone: endoproteolytic processing and differential release of its derived peptides within AtT20 cells”. Mol. Cell. Endocrinol. 142 (1–2): 191—202. PMID 9783915. doi:10.1016/S0303-7207(98)00104-X.
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Spoljašnje veze

Corticotropin-releasing на US National Library of Medicine Medical Subject Headings (MeSH)

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[entrez-1] „Entrez Gene: CRH corticotropin releasing hormone”.

[pmid6267699-2] Vale W, Spiess J, Rivier C, Rivier J (1981). „Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin”. Science (journal). 213 (4514): 1394—7. PMID 6267699. doi:10.1126/science.6267699.

[pmid2982307-3] Chrousos GP, Schuermeyer TH, Doppman J, Oldfield EH, Schulte HM, Gold PW, Loriaux DL (1985). „NIH conference. Clinical applications of corticotropin-releasing factor.”. Annals of internal medicine. 102 (3): 344—358. PMID 2982307.

[pmid10598591-4] Grammatopoulos, D K; Dai Y; et al. (1999). „A novel spliced variant of the type 1 corticotropin-releasing hormone receptor with a deletion in the seventh transmembrane domain present in the human pregnant term myometrium and fetal membranes”. Mol. Endocrinol. UNITED STATES. 13 (12): 2189—202. ISSN 0888-8809. PMID 10598591. doi:10.1210/me.13.12.2189.

[pmid9423932-5] Gottowik, J; Goetschy V; et al. (1997). „Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin”. Neuropharmacology. ENGLAND. 36 (10): 1439—46. ISSN 0028-3908. PMID 9423932. doi:10.1016/S0028-3908(97)00098-1.

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